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Direct-Acting Sympathomimetics: Norepinephrine-Chemical formula, Mechanism of Action, Uses & Effect

Norepinephrine (Noradrenaline)

Chemical Structure/Formula

  • C8H11NO3

Structure of Norepinephrine (Noradrenaline)
Structure of Norepinephrine (Noradrenaline)

Mechanism of Action:

  • Norepinephrine acts primarily as a neurotransmitter and hormone in the central and peripheral nervous systems.

  • It binds predominantly to alpha-adrenergic receptors, causing vasoconstriction and increasing blood pressure.

  • It also has a minor effect on beta receptors, which can lead to increased heart rate.

Uses:

  • It is mainly used to treat life-threatening low blood pressure (hypotension) that can occur with certain medical conditions or surgical procedures.

Side Effects:

  • Common side effects include headache, slow heart rate (bradycardia), arrhythmias, anxiety, and hypertension.


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