Dissociation Constant

Definition: 

• The dissociation constant is a measure of the extent to which a compound separates into its components in solution.

For a general reaction:

• the dissociation constant is given by:

Properties:

• Equilibrium: Indicates the position of equilibrium for dissociation reactions.

• Strength of Interaction: A lower Kd​ value indicates a stronger interaction between the components.

Determination:

• Spectroscopy: Measuring concentrations of components at equilibrium.

• Titration: Determining the concentration of dissociated ions.

Applications of Dissociation Constant:

• Biochemistry: Studying binding affinities of enzymes and substrates.

• Pharmacology: Determining drug-receptor interactions.

• Chemistry: Understanding reaction dynamics and stability of complexes.