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Doxylamine Succinate

Structure (Doxylamine Succinate)

  • Doxylamine succinate is a first-generation antihistamine with a tricyclic structure.

  • It is paired with succinic acid to form a salt, improving solubility.

  • Chemical Formula: C₁₉H₂₉NO₃·C₄H₆O₄

Structure Doxylamine Succinate
Structure Doxylamine Succinate

Mode of Action

  • Functions as an H₁-receptor antagonist with anticholinergic and sedative properties.

  • It inhibits the action of histamine at peripheral and central H₁ receptors.

Uses

  • Insomnia: Used as a short-term treatment for sleep disturbances.

  • Allergic Reactions: Relieves symptoms of allergic rhinitis and urticaria.

  • Cold Symptoms: Alleviates runny nose and sneezing


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