Doxylamine Succinate

Structure

• Doxylamine succinate is a first-generation antihistamine with a tricyclic structure.

• It is paired with succinic acid to form a salt, improving solubility.

• Chemical Formula: C₁₉H₂₉NO₃·C₄H₆O₄

Structure Doxylamine Succinate

Mode of Action

• Functions as an H₁-receptor antagonist with anticholinergic and sedative properties.

• It inhibits the action of histamine at peripheral and central H₁ receptors.

Uses of Doxylamine Succinate

• Insomnia: Used as a short-term treatment for sleep disturbances.

• Allergic Reactions: Relieves symptoms of allergic rhinitis and urticaria.

• Cold Symptoms: Alleviates runny nose and sneezing