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Drugs acting on Endocrine system

  • Endocrine system is a group of glands that release hormones that control a variety of physiological processes in the body, including growth, sexual function, metabolism, Etc.,

  • These glands are ductless which directly secrete their hormones into the blood.

  • This system also helps to maintain internal homeostasis using hormones.

Hormones-

  • Body's chemical messengers are called hormones.

  • They move to tissues or organs in the body via the bloodstream.

  • They act slowly over time and have an impact on a variety of activities, including growth, development, and metabolism.

  • Another name for these substances is signaling molecules.

  • These substances function at extremely low concentrations.

  • They have an effect on the targeted cells.

  • Immediately destroyed after serving their function.

  • It might be amines, peptides, steroids, etc.

STEROIDS

  • A steroid is a biologically active organic compound with four rings arranged in a specific molecular configuration.

  • These compounds have 4 steroidal rings which contain 17 carbons.

Nomenclature

  • Four rings are joined to form steroids (A, B, C, and D). These hydrocarbons are cyclopentane per hydro phenanthrenes chemically speaking.

steroids consist of four fused rings
  • They include the three phenanthrene rings as well as a five-membered cyclopentane (D) ring.

  • The saturated derivative of phenanthrene is called a perhydro phenanthrene (rings A, B, and C).

phenanthrene
  • To explain the numbering system for a steroid, the polycyclic hydrocarbon 5-α-cholestane is used.

cholestane
  • In the structure of 5α-cholestane, the ring carbons are shown by a thick, dark line.

  • Groups above the plane of the nucleus are shown by solid lines known as β-configuration, and groups below the plane are indicated by dotted lines known as α-configuration.

  • A C = C bond in a steroid is frequently denoted by the symbol Δ. A molecule is referred to as a Δ4 steroid" if the C = C bond is located between carbons 5 and 4, and a Δ5(10) steroid" if it is located between carbons 5 and 10.

  • example - Estra-Δ1,3,5(10) triene-3,17Beta-diol

estradiol
estradiol
oidnomenclature of steroids

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