Eflornithine
- BP-S-6-Medicinal Chemistry III
- Apr 3
- 1 min read
Chemical Structure / Formula of Eflornithine
Formula: C6H12F2N2O2
Structure: Fluorinated ornithine analog.
Mechanism of Action
Inhibits ornithine decarboxylase, blocking polyamine synthesis, which is essential for Trypanosoma growth.
Uses
Trypanosomiasis (African sleeping sickness: first-line for late-stage disease).
Side Effects
Bone marrow suppression (anemia, leukopenia).
Seizures, neurotoxicity.
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