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Sodium Chloride (NaCl): Electrolytes Used in Replacement Therapy

Preparation:

  • Natural Sources: Sodium chloride, commonly known as table salt, is primarily obtained through the evaporation of seawater or brine from salt mines.

  • Chemical Production: It can also be produced through a chemical reaction between sodium hydroxide or sodium carbonate and hydrochloric acid:

a) NaOH + HCl → NaCl + H2O

b) Na2CO3 + 2HCl → 2NaCl + H2O + CO2

Properties:

  • White, crystalline solid

  • Melting point: 801°C (1474°F)

  • Boiling point: 1413°C (2575°F)

  • Highly soluble in water, forming a clear, colorless solution

  • Saline taste and odorless

  • Ionic compound consisting of Na+ and Cl− ions.

Uses of Sodium Chloride:

  • Widely used as a seasoning and preservative in the food industry

  • Key component in intravenous fluids and oral rehydration solutions for treating dehydration and electrolyte imbalances

  • Used in isotonic saline solutions for nasal sprays, eye drops, and wound irrigation

  • Employed in water softening, de-icing roads, and various industrial processes.

Assay:

  • Assayed using titration methods such as the Volhard method or the Mohr method.

  • Volhard Method: Involves adding a known excess of silver nitrate to the sodium chloride solution. The unreacted silver nitrate is then titrated with a standard solution of potassium thiocyanate using ferric ammonium sulfate as an indicator.

  • Mohr Method: The sodium chloride solution is titrated with a standard solution of silver nitrate using potassium chromate as an indicator.


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