Structure of Enalapril
Enalapril is a prodrug ACE inhibitor converted to enalaprilat in vivo, featuring a proline derivative linked to a diethyl ester.
Chemical Formula: C₁₇H₂₅N₃O₅
Structure of Enalapril
Mode of Action
Prodrug Activation: Converted to active enalaprilat in the liver.
ACE Inhibition: Blocks the formation of angiotensin II, leading to vasodilation and reduced aldosterone secretion.
Renal Effects: Protects against renal scarring in diabetic and hypertensive nephropathy.
Uses
Hypertension: Lowers blood pressure by reducing angiotensin II levels.
Heart Failure: Enhances cardiac function by reducing afterload and preload.
Post-Myocardial Infarction: Prevents adverse remodeling and improves survival rates.
Diabetic Nephropathy: Slows the progression of kidney disease in diabetic patients.