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Ethacrynic acid

Structure of Ethacrynic acid

  • Ethacrynic acid is a non-sulfonamide loop diuretic with a vinyl group and a double bond, distinguishing it from other loop diuretics.

  • Chemical Formula: C₁₂H₁₅NO₄

    Structure of Ethacrynic acid
    Structure of Ethacrynic acid

Mode of Action

  • Loop of Henle Inhibition: Inhibits the Na⁺/K⁺/2Cl⁻ symporter in the ascending limb of the loop of Henle.

  • Sodium, Potassium, Chloride Excretion: Promotes significant diuresis by increasing the excretion of these ions.

  • Calcium and Magnesium Retention: Enhances reabsorption of calcium and magnesium, reducing kidney stone risk.

Uses

  1. Edema: Treats fluid retention in congestive heart failure, renal disease, and liver cirrhosis.

  2. Hypertension: Utilized to lower blood pressure by reducing blood volume.

  3. Hypercalcemia: Manages elevated calcium levels through increased excretion.

  4. Acute Pulmonary Edema: Provides rapid diuresis to relieve lung congestion.

  5. Hyponatremia: Addresses low sodium levels by promoting sodium excretion.


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