Structure of Ethacrynic acid
Ethacrynic acid is a non-sulfonamide loop diuretic with a vinyl group and a double bond, distinguishing it from other loop diuretics.
Chemical Formula: C₁₂H₁₅NO₄
Structure of Ethacrynic acid
Mode of Action
Loop of Henle Inhibition: Inhibits the Na⁺/K⁺/2Cl⁻ symporter in the ascending limb of the loop of Henle.
Sodium, Potassium, Chloride Excretion: Promotes significant diuresis by increasing the excretion of these ions.
Calcium and Magnesium Retention: Enhances reabsorption of calcium and magnesium, reducing kidney stone risk.
Uses
Edema: Treats fluid retention in congestive heart failure, renal disease, and liver cirrhosis.
Hypertension: Utilized to lower blood pressure by reducing blood volume.
Hypercalcemia: Manages elevated calcium levels through increased excretion.
Acute Pulmonary Edema: Provides rapid diuresis to relieve lung congestion.
Hyponatremia: Addresses low sodium levels by promoting sodium excretion.