Ethacrynic acid

Structure of Ethacrynic acid

• Ethacrynic acid is a non-sulfonamide loop diuretic with a vinyl group and a double bond, distinguishing it from other loop diuretics.

• Chemical Formula: C₁₂H₁₅NO₄

  

  Structure of Ethacrynic acid

Mode of Action

• Loop of Henle Inhibition: Inhibits the Na⁺/K⁺/2Cl⁻ symporter in the ascending limb of the loop of Henle.

• Sodium, Potassium, Chloride Excretion: Promotes significant diuresis by increasing the excretion of these ions.

• Calcium and Magnesium Retention: Enhances reabsorption of calcium and magnesium, reducing kidney stone risk.

Uses

1. Edema: Treats fluid retention in congestive heart failure, renal disease, and liver cirrhosis.

2. Hypertension: Utilized to lower blood pressure by reducing blood volume.

3. Hypercalcemia: Manages elevated calcium levels through increased excretion.

4. Acute Pulmonary Edema: Provides rapid diuresis to relieve lung congestion.

5. Hyponatremia: Addresses low sodium levels by promoting sodium excretion.