Structure
Ethacrynic acid Chemical Structure – C13H12Cl2O4
Mode of action
It produces a diuretic effect by competitively inhibiting sodium-potassium-chloride cotransporters in the nephron and blocking the transport of sodium ions during reabsorption.
Due to this inhibition, more water, sodium, chloride, magnesium, calcium, hydrogen, and potassium ions are excreted.
It produces pharmacological effect through ion excretion, increased urine flow, and a decrease in extracellular fluid.
Uses
It is used to treat edema and ascites.