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Ethionamide: Chemical Structure, Mechanism of action, Uses & Side effects

Chemical formula:

  • C8H10N2S

Structure of Ethionamide
Structure of Ethionamide

Mechanism of action:

  • Ethionamide is a prodrug that is activated by the mycobacterial enzyme EthA.

  • The activated compound inhibits the synthesis of mycolic acid by targeting the enzyme enoyl-acyl carrier protein reductase (InhA), thereby inhibiting the growth of Mycobacterium tuberculosis.

Uses:

  • Ethionamide is used in the treatment of multidrug-resistant tuberculosis (MDR-TB), usually in combination with other antitubercular drugs.

Side effects:

  • Side effects can include gastrointestinal disturbances, hepatotoxicity, neurotoxicity, hypersensitivity reactions, and endocrine disturbances.


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