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Etoposide

Structure of Etoposide

  • Etoposide is a podophyllotoxin derivative featuring a dioxolane ring and a dihydropyran ring linked to a benzene ring.

  • Chemical Formula: C₂₀H₁₄O₆

Structure of Etoposide
Structure of Etoposide

Mode of Action

  • Topoisomerase II Inhibition: Prevents DNA strand re-ligation, causing DNA breaks.

  • DNA Damage: Leads to cell cycle arrest and apoptosis in rapidly dividing cells.

  • Apoptosis Induction: Triggers programmed cell death in cancerous cells.

Uses

  1. Testicular Cancer: Particularly effective in combination with other agents.

  2. Lung Cancer: Small cell and non-small cell types.

  3. Lymphomas: Including Hodgkin's and non-Hodgkin's lymphoma.

  4. Leukemias: Acute myeloid and lymphoblastic leukemia.

  5. Bone and Soft Tissue Sarcomas: As part of multi-agent chemotherapy regimens.


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