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Eutectic mixture

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  • Eutectic mixtures can present challenges during the formulation, compounding, and storage of the final product.

  • When two or more components in a powder formulation form a eutectic mixture, they can create a mass that is sticky, pasty, or even liquid-like at or near the eutectic melting point, which is lower than the melting points of the individual components.

  • These altered physical properties can cause difficulties in handling, processing, and maintaining the stability of the final powder dosage form.

  • The eutectic mixture may also impact the drug release profile, bioavailability, and overall therapeutic efficacy of the final product.

Strategies to Address Eutectic Mixtures

1) Physical separation of the components

  • Microencapsulation can be used to coat one or both components, preventing direct contact and avoiding eutectic formation.

2) Modification of the components

  • Chemical or physical modifications, such as using different salts, polymorphs, or solvates, can alter melting points and reduce eutectic formation.

3) Use of additives

  • Diluents, stabilizers, or anti-caking agents can help prevent eutectic formation by absorbing moisture, reducing interactions, or altering melting points.

4) Controlling the storage conditions

  • Temperature and humidity control can help prevent eutectic formation by maintaining storage conditions below the eutectic melting point.

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