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Factors Affecting Ion Exchange

  1. Nature of the Resin: Functional groups and crosslinking influence selectivity, capacity, and exchange rate.

  2. pH of the Mobile Phase: Affects the charge state of ionizable compounds, influencing binding.

  3. Ionic Strength: Higher ionic strength can promote elution through increased ion competition.

  4. Temperature: Impacts exchange kinetics and resin capacity.

  5. Particle Size of the Resin: Smaller particles offer better resolution but may increase back pressure.

  6. Flow Rate: Must balance between sufficient contact time for exchange and process efficiency.

  7. Concentration of Sample Ions: High concentrations can saturate the resin, reducing separation efficiency


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