Structure of Famotidine
Famotidine is a second-generation H₂-receptor antagonist characterized by a thiazole ring linked to a guanidine moiety and a difluoromethyl group.
Chemical Formula: C₈H₉N₇O₂S₂
Mode of Action
Famotidine competitively inhibits H₂ receptors on gastric parietal cells, leading to decreased gastric acid secretion.
It has a higher affinity for H₂ receptors compared to first-generation antagonists, resulting in prolonged action.
Uses
Peptic Ulcers: Facilitates healing by reducing acid secretion.
GERD: Relieves symptoms by lowering stomach acidity.
Zollinger-Ellison Syndrome: Controls excessive acid production.
Prevention of NSAID-Induced Ulcers: Protects against ulcer formation in patients taking nonsteroidal anti-inflammatory drugs.