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Filling, Finishing, and Special Techniques of Formulation

Filling:

  • Hard gelatin capsules can be filled using various methods depending on the formulation:

    1. Powders and Granules: Direct filling using tamping or auger mechanisms.

    2. Pellets: Placed inside the capsule as pre-formed units.

    3. Liquids and Semi-solids: Requires sealing to prevent leakage.

    4. Tablet-in-Capsule: Combines a pre-made tablet and powder within the capsule.

Finishing:

  • After filling, capsules are polished to remove dust or adhering particles. Common methods include:

  • Brushing: Capsules are rotated against soft brushes.

  • Cloth Polishing: Capsules are passed through a polishing pan lined with soft fabric.

Special Techniques:

  • Band Sealing: Sealing the capsule with a gelatin band to prevent tampering or leakage.

  • Spray Coating: Coating capsules with enteric or controlled-release polymers.

  • Liquid-Filled Capsules: Using advanced techniques to fill liquids with appropriate sealing.


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