Furazolidine
- BP-S-6-Medicinal Chemistry III
- Mar 31
- 1 min read
Chemical Structure / Formula of Furazolidine
Formula: C8H7N3O5
Structure: Nitrofuran derivative with an oxazolidinone ring.
Mechanism of Action
Prodrug activated by bacterial nitroreductases, generating reactive oxygen species (ROS).
These radicals damage bacterial DNA, proteins, and cell membranes, leading to cell death.
Uses
UTIs caused by Gram-positive and Gram-negative bacteria.
Giardiasis, cholera, and enteric infections (E. coli, Salmonella, Shigella, etc.).
Limited modern use due to availability of better alternatives.
Side Effects
GI upset (nausea, vomiting, diarrhea).
Peripheral neuropathy (long-term use).
Hemolysis in G6PD-deficient patients.
Disulfiram-like reaction (avoid alcohol).
