Gastric proton pump inhibitor class of drugs known as proton-pump inhibitors (PPIs) rapidly and continuously reduce stomach acid production. They accomplish this by permanently blocking the H+/K+ ATPase proton pump in the stomach.
It is used to control the gastric acidity and ulcers.
Medical Uses of H1 antagonist-
These drugs are used to treat a variety of disease, including:
Dyspepsia
stomach ulcer illness
Disease of the gastroesophageal reflux
Prevention of stress gastritis and ulcers in critical care
Side effects-Blurred vision
Proton pump inhibitors are usually well tolerated, and the probability of temporary side effects is low. The variety of side effects are-
Nausea
Vomiting
abdominal discomfort
flatulence
constipation
diarrhoea
Mechanism of action
The enzyme H+/K+ ATPase is found on the parietal cells of the stomach and responsible for HCL secretion.
Sulphonyl groups are found in proton pump inhibitors as a bridge between substituted benzimidazoles and pyridine rings.
when parietal cells were first Introduced to PPI. Its sulphonyl group interacts with the enzyme H+/K+ ATPase, releasing the drug enzyme complex.
Which further metabolized easily and irreversible inactivates the proton pump.
Now that H+ ions do not secrete out, HCl production decreases.
It blocks gastric acid secretion even its histamine with their receptor.
Here is the diagram for the classification of Gastric Proton Pump Inhibitors: