Chemical Formula:
C19H22FN3O4
Mechanism of Action:
Gatifloxacin is a fourth-generation fluoroquinolone antibiotic.
It acts by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes responsible for the unwinding and supercoiling of bacterial DNA.
This inhibition prevents DNA replication, transcription, and repair, ultimately leading to bacterial cell death.
Uses:
Gatifloxacin is used to treat a variety of bacterial infections, including:
Acute bacterial sinusitis
Acute bacterial exacerbation of chronic bronchitis
Community-acquired pneumonia
Uncomplicated skin and skin structure infections
Side Effects:
Some common side effects of gatifloxacin include:
Nausea
Diarrhea
Headache
Dizziness
Abdominal pain
Vomiting
Serious side effects may include:
Tendon rupture or inflammation
Peripheral neuropathy
Central nervous system effects (e.g., seizures, anxiety, depression)
Photosensitivity
Hypersensitivity reactions
QT interval prolongation
Clostridium difficile-associated diarrhea