Geometric dilutions
- S-1-Pharmaceutics I
- Feb 27
- 1 min read
Updated: Apr 9
Geometric dilution is a compounding technique used in pharmacy to achieve a homogeneous mixture when combining ingredients with significantly different quantities.
This method ensures even distribution of a potent active ingredient with a larger amount of diluent or excipient, which is crucial for maintaining accurate dosing and consistent therapeutic effects.
Steps in Geometric Dilution
1) Start with the Smallest Quantity
Begin with the smallest quantity ingredient, usually the potent active ingredient, and mix it with an equal amount of the diluent or excipient.
2) Initial Mixing
Thoroughly mix the active ingredient and the diluent using a mortar and pestle or a spatula in a suitable container. This step ensures that the active ingredient is evenly distributed in the initial portion of the diluent.
3) Doubling the Mixture
Take the mixture from step 2 and add an equal amount of the remaining diluent or excipient.
4) Mix Thoroughly
Again, thoroughly mix the new combination to ensure uniformity.
5) Repeat the Process
Continue adding equal portions of the remaining diluent or excipient, mixing thoroughly each time, until all the diluent has been incorporated, and a homogeneous mixture is achieved.
Importance of Geometric Dilution
Accurate Dosing: Especially important for potent drugs, where small variations in the distribution of the active ingredient can lead to significant differences in therapeutic effects.
Consistency: Ensures the uniform distribution of the active ingredient, providing consistent therapeutic outcomes.
Geometric dilution is a fundamental technique in pharmaceutical compounding to ensure even blending of ingredients, particularly when dealing with large disparities in ingredient quantities.
