Structure
Glimepiride is a third-generation sulfonylurea with a triazole ring, providing enhanced selectivity and reduced side effects.
Chemical Formula: C₂₁H₂₄ClN₅O₃S
Mode of Action
Enhanced Selectivity: More selective for pancreatic beta cells, reducing off-target effects.
Increased Potency: Lower doses achieve desired insulinotropic effects.
Uses
Type 2 Diabetes Mellitus: Improves glycemic control with lower risk of hypoglycemia.
Combination Therapy: Used alongside other antidiabetic agents for synergistic effects.