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Glimepiride

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Structure

  • Glimepiride is a third-generation sulfonylurea with a triazole ring, providing enhanced selectivity and reduced side effects.

  • Chemical Formula: C₂₁H₂₄ClN₅O₃S

    Glimepiride
Structure of Glimepiride
Structure of Glimepiride

Mode of Action

  • Enhanced Selectivity: More selective for pancreatic beta cells, reducing off-target effects.

  • Increased Potency: Lower doses achieve desired insulinotropic effects.

Uses

  • Type 2 Diabetes Mellitus: Improves glycemic control with lower risk of hypoglycemia.

  • Combination Therapy: Used alongside other antidiabetic agents for synergistic effects.


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