Structure
Glipizide is a second-generation sulfonylurea with a substituted imidazolidine ring, offering improved potency and shorter half-life.
Chemical Formula: C₁₅H₂₀ClN₃O₃S
Mode of Action
ATP-Sensitive K⁺ Channel Blockade: Stimulates insulin release.
Shorter Half-Life: Reduces risk of prolonged hypoglycemia.
Uses
Type 2 Diabetes Mellitus: Effective in controlling postprandial and fasting blood glucose levels.
Combination Therapy: Often combined with metformin for enhanced glycemic control.