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Glipizide

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Structure

  • Glipizide is a second-generation sulfonylurea with a substituted imidazolidine ring, offering improved potency and shorter half-life.

  • Chemical Formula: C₁₅H₂₀ClN₃O₃S

Structure of Glipizide
Structure of Glipizide

Mode of Action

  • ATP-Sensitive K⁺ Channel Blockade: Stimulates insulin release.

  • Shorter Half-Life: Reduces risk of prolonged hypoglycemia.

Uses

  • Type 2 Diabetes Mellitus: Effective in controlling postprandial and fasting blood glucose levels.

  • Combination Therapy: Often combined with metformin for enhanced glycemic control.


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