Structure of Guanabenz acetate
Guanabenz acetate is a guanidine derivative with an aromatic ring substituted with an ethylene bridge connecting to a guanidine moiety.
Chemical Formula: C₁₀H₁₉N₃O₂S
Mode of Action
Alpha-2 Adrenergic Agonism: Activates central alpha-2 receptors, reducing sympathetic outflow.
Sympathetic Inhibition: Lowers blood pressure by decreasing peripheral vascular resistance.
Enhanced Receptor Sensitivity: Increases the responsiveness of central alpha-2 receptors to endogenous norepinephrine.
Uses
Hypertension: Used in the management of essential hypertension.
Congestive Heart Failure: Reduces afterload and preload, improving cardiac output.
Rheumatoid Arthritis: Employed off-label for its immunomodulatory effects.
Preeclampsia: Manages high blood pressure in pregnant women with preeclampsia.