Structure of Guanethidine Monosulphate
Guanethidine Monosulphate is a guanidine derivative featuring a guanidine moiety linked to an aromatic ring via an ethylene bridge.
Chemical Formula: C₁₄H₁₉N₃O₆S
Mode of Action
Sympathetic Inhibition: Blocks norepinephrine release from postganglionic sympathetic neurons by disrupting storage vesicles.
Peripheral Effects: Reduces peripheral vascular resistance and cardiac output, lowering blood pressure.
Renal Effects: Decreases renin secretion, contributing to blood pressure reduction.
Uses
Hypertension: Primarily used in severe or resistant hypertension.
Pheochromocytoma: Manages blood pressure before surgical removal of the tumor.
Peripheral Vascular Disease: Improves blood flow by reducing vascular resistance.
Chronic Pain: Sometimes used off-label for its sympatholytic effects.