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H-2 ANTAGONISTS

radhika5608
1 min read

  • Histamine H2 receptors are found on the parietal cells in the stomach, a

  • H2-Antagonist are the class of drugs known as H2 blockers prevents histamine from acting on those receptors. Due to this, less stomach acid is produced.

  • This type of drug used in the treatment of gastric acid, duodenal ulcers dyspepsia, peptic ulcers, and gastroesophageal reflux disease.

Medical Uses of H2 antagonist-

  • Gastroesophageal reflux disease

  • Dyspepsia

  • Stress ulcers

  • Prevention of aspiration pneumonitis during surgery.

Side effects-Blurred vision

  • Hypotension

  • Headache

  • Tiredness

  • Dizziness

  • Diarrhoea

  • Constipation

  • Rash

Mechanism of action

  • When histamine releases, it binds with H2 receptor.

  • H2 receptor ae also G-protein coupled receptors, so it activates cAMP.

  • This cAMP increases the Ca++ which further increases the or activates the proton pump and increase the secretion of H+, which further increases the production of HCl.

  • H2- Antagonist blocks the receptors so all the mechanism inhibits, and all the action of histamine reduced. So HCl secretion decreases.

classification of H2-antagonists

Here is the diagram for the classification of H2-antagonists:


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