Structure of Hydralazine Hydrochloride
Hydralazine hydrochloride is a non-sulfonamide vasodilator with a pyrazoline core containing two aromatic rings and amino groups.
Chemical Formula: C₆H₇N₃O · HCl
Mode of Action
Direct Arteriolar Vasodilation: Relaxes vascular smooth muscle, decreasing peripheral vascular resistance.
Reduction of Afterload: Lowers systemic blood pressure by causing arteriolar dilation.
Prostaglandin Release: May induce the release of prostaglandins, contributing to vasodilation.
Uses
Hypertension: Especially useful in pregnancy-induced hypertension and hypertensive emergencies.
Heart Failure: Reduces afterload, improving cardiac output.
Renal Artery Stenosis: Manages hypertension associated with renal artery narrowing.
Heart Failure in Combination Therapy: Used alongside beta-blockers and ACE inhibitors for optimal management.