Structure of Hydroflumethiazide
Hydroflumethiazide is a thiazide diuretic with a fluorine atom substitution, enhancing its potency and duration of action.
Chemical Formula: C₈H₈ClF₅N₃O₄S₂
Mode of Action
Thiazide Receptor Blocking: Inhibits the sodium-chloride symporter in the distal convoluted tubule.
Sodium and Chloride Excretion: Induces diuresis by increasing excretion of sodium and chloride ions.
Potassium Loss: Promotes excretion of potassium and hydrogen ions, potentially leading to hypokalemia and metabolic alkalosis.
Uses
Hypertension: Effective in lowering blood pressure through volume and vascular resistance reduction.
Edema: Manages fluid retention in conditions like congestive heart failure, liver cirrhosis, and renal disease.
Nephrolithiasis Prevention: Helps prevent the formation of calcium-based kidney stones.
Heart Failure: Employed as part of diuretic regimens to control edema.