Base Adsorption:
Base adsorption is the weight of the solid drug or excipients adsorbed per gram of liquid carrier (base).
This concept is crucial when suspending drugs in the liquid or semi-solid fill.
Significance:
Prevents sedimentation of the drug within the capsule.
Improves uniformity and ensures consistent drug delivery.
Helps in calculating the fill weight for accurate dosing.
Minim/Gram Factor:
Minim/gram factor is a measure of the weight of the fill material (in grams) that corresponds to one minim of the formulation.
Importance:
Ensures proper compatibility of the liquid fill material with the shell.
Determines the amount of liquid fill that can be encapsulated within a specific capsule size.