Indomethacin: Chemical Structure, Mechanism of Action, Uses, Side Effects

Chemical Structure:

• C19H16ClNO4

Chemical Structure

Mechanism of Action:

• Indomethacin is a potent non-selective COX inhibitor. It effectively reduces prostaglandin synthesis, providing strong anti-inflammatory effects.

Uses:

• Used primarily as an anti-inflammatory agent in various conditions like arthritis, gout, and bursitis. It's also used to close patent ductus arteriosus, a heart defect in premature infants.

Side Effects:

• It can cause gastrointestinal irritation, risk of gastrointestinal bleeding, renal impairment, and central nervous system effects such as headache and dizziness.