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Gastroretentive Drug Delivery Systems (GRDDS)

Introduction to Gastroretentive Drug Delivery Systems

  • Gastroretentive Drug Delivery Systems are designed to prolong the gastric residence time of drugs, enhancing their bioavailability and therapeutic efficacy.

  • These systems are particularly beneficial for drugs that are absorbed primarily in the stomach or upper small intestine, have a narrow absorption window, or are unstable in the intestinal or colonic environment.

Gastroretentive Drug Delivery Systems (GRDDS)

Advantages

  • Enhanced Bioavailability: Prolonged gastric retention increases the absorption of drugs with narrow absorption windows.

  • Improved Therapeutic Effect: Maintains steady plasma drug concentrations.

  • Reduced Dosing Frequency: Enhances patient compliance by reducing the need for frequent dosing.

  • Targeted Delivery: Beneficial for local treatment of gastric diseases.

Disadvantages

  • Variability in Gastric Emptying: Gastric residence time can be unpredictable due to physiological factors.

  • Potential for Gastric Irritation: Prolonged contact with the gastric mucosa may cause irritation.

  • Complex Formulation: Developing a system that remains in the stomach requires sophisticated design.


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