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Introduction to Transdermal Drug Delivery Systems (TDDS)

  • Transdermal Drug Delivery Systems (TDDS) are self-contained, discrete dosage forms designed to deliver drugs through the skin at a controlled rate directly into the systemic circulation.

  • These systems, commonly available as patches or gels, provide a non-invasive and effective method for administering medications.

Transdermal Drug Delivery Systems (TDDS)
Transdermal Drug Delivery Systems (TDDS)

Advantages

  1. Bypass First-Pass Metabolism: Avoids liver metabolism, reducing drug degradation.

  2. Sustained Release: Maintains constant drug levels, improving effectiveness and reducing side effects.

  3. Patient-Friendly: Non-invasive, convenient, and reduces dosing frequency.

  4. Less Side Effects: Targeted delivery minimizes systemic side effects.

  5. Easy Termination: Therapy can be stopped by simply removing the patch.

Disadvantages of Transdermal Drug Delivery Systems

  1. Skin Irritation: May cause local reactions.

  2. Skin Barrier: The outer skin layer limits drug penetration.

  3. Drug Suitability: Only works for potent drugs with specific properties.

  4. Drug Residue: Wastage may occur due to leftover drug in the patch.

  5. Visibility: Some patients may find patches cosmetically unappealing.

TDDS offers a non-invasive alternative for drug delivery but has limitations related to drug properties and skin compatibility.


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