Transdermal Drug Delivery Systems (TDDS) are self-contained, discrete dosage forms designed to deliver drugs through the skin at a controlled rate directly into the systemic circulation.
These systems, commonly available as patches or gels, provide a non-invasive and effective method for administering medications.
Advantages
Bypass First-Pass Metabolism: Avoids liver metabolism, reducing drug degradation.
Sustained Release: Maintains constant drug levels, improving effectiveness and reducing side effects.
Patient-Friendly: Non-invasive, convenient, and reduces dosing frequency.
Less Side Effects: Targeted delivery minimizes systemic side effects.
Easy Termination: Therapy can be stopped by simply removing the patch.
Disadvantages of Transdermal Drug Delivery Systems
Skin Irritation: May cause local reactions.
Skin Barrier: The outer skin layer limits drug penetration.
Drug Suitability: Only works for potent drugs with specific properties.
Drug Residue: Wastage may occur due to leftover drug in the patch.
Visibility: Some patients may find patches cosmetically unappealing.
TDDS offers a non-invasive alternative for drug delivery but has limitations related to drug properties and skin compatibility.