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Isoflurane: Chemical Structure, Mechanism of Action, Uses & Side Effects

Chemical Structure:

  • C3H2ClF5O

Chemical Structure
Chemical Structure

Mechanism of Action:

  • GABAergic Enhancement: Acts to potentiate GABA, leading to a decrease in neuronal activity.

  • Ion Channel Modulation: Affects the function of various ion channels, impacting nerve cell excitability and synaptic transmission.

Uses:

  • General Anesthesia: Commonly used due to its balance of safety and efficacy.

Side Effects:

  • Respiratory Depression: A standard effect of inhalational anesthetics.

  • Hypotension: Can cause a decrease in blood pressure.

  • Malignant Hyperthermia Risk: Though rare, this is a serious concern with many anesthetics, including isoflurane.

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