Chemical formula:
C35H38Cl2N8O4
Mechanism of action:
Itraconazole is a triazole antifungal that inhibits the synthesis of ergosterol in fungal cell membranes, causing membrane disruption and fungal cell death.
Uses:
Itraconazole is used to treat various fungal infections, such as histoplasmosis, blastomycosis, and aspergillosis. It is also effective against various dermatophyte and Candida infections.
Side effects:
Common side effects include gastrointestinal disturbances, such as nausea, vomiting, or diarrhea. Other side effects may include headache, dizziness, and skin rash. In rare cases, it can cause hepatotoxicity (liver damage) or congestive heart failure.