Itraconazole
- BP-S-6-Medicinal Chemistry III
- 5 days ago
- 1 min read
Chemical Structure / Formula of Itraconazole
Formula: C35H38Cl2N8O4
Structure: Triazole antifungal with lipophilic side chains.
Mechanism of Action
Inhibits lanosterol 14α-demethylase, preventing ergosterol synthesis.
Uses
Systemic fungal infections (Histoplasmosis, Aspergillosis, Candidiasis, Blastomycosis).
Onychomycosis (fungal nail infections).
Side Effects
Hepatotoxicity, GI upset, headache.
Heart failure risk (black box warning: negative inotropic effects).
