Structure
L-Thyronine, also known as triiodothyronine (T3), is a thyroid hormone with a tyrosine backbone and three iodine atoms.
Chemical Formula: C₁₇H₁₅I₃NO₄
Mode of Action
Thyroid Hormone Replacement: Acts similarly to endogenous T3, binding to thyroid hormone receptors and regulating gene transcription.
Metabolic Enhancement: Increases basal metabolic rate, enhances lipolysis, and promotes thermogenesis.
Growth and Development: Critical for normal growth, neurological development, and differentiation in tissues.
Cardiovascular Effects: Increases heart rate, cardiac contractility, and enhances cardiac output.
Uses
Hypothyroidism: Used when rapid thyroid hormone action is required or in cases where T4 conversion to T3 is impaired.
Myxedema Coma: Emergency treatment of severe hypothyroidism alongside L-Thyroxine.
Goiter: Manages thyroid enlargement by providing negative feedback on TSH secretion.
Thyroid Cancer: As part of adjuvant therapy to suppress TSH and inhibit tumor growth.
Research: Employed in studies on thyroid hormone physiology and metabolism.