Lansoprazole

Structure of Lansoprazole

• Lansoprazole is a benzimidazole derivative similar to Omeprazole, featuring a pyridine ring fused to a benzimidazole core, a sulfoxide group, and an ethoxy group.

• Chemical Formula: C₁₆H₁₈F₂N₃O₂S

  

  Structure of Lansoprazole

Mode of Action

• Lansoprazole acts as a proton pump inhibitor by irreversibly binding to the H⁺/K⁺-ATPase enzyme in gastric parietal cells, thereby inhibiting gastric acid secretion.

• It forms a covalent disulfide bond with the proton pump, leading to sustained acid suppression.

Uses

1. Peptic Ulcers: Facilitates healing by lowering acid production.

2. GERD: Reduces acid reflux and related symptoms.

3. Zollinger-Ellison Syndrome: Controls excessive acid secretion.

4. Erosive Esophagitis: Promotes healing of esophageal inflammation.

5. Helicobacter pylori Eradication: Used in combination with antibiotics for eradication therapy.