Structure of Lansoprazole
Lansoprazole is a benzimidazole derivative similar to Omeprazole, featuring a pyridine ring fused to a benzimidazole core, a sulfoxide group, and an ethoxy group.
Chemical Formula: C₁₆H₁₈F₂N₃O₂S
Structure of Lansoprazole
Mode of Action
Lansoprazole acts as a proton pump inhibitor by irreversibly binding to the H⁺/K⁺-ATPase enzyme in gastric parietal cells, thereby inhibiting gastric acid secretion.
It forms a covalent disulfide bond with the proton pump, leading to sustained acid suppression.
Uses
Peptic Ulcers: Facilitates healing by lowering acid production.
GERD: Reduces acid reflux and related symptoms.
Zollinger-Ellison Syndrome: Controls excessive acid secretion.
Erosive Esophagitis: Promotes healing of esophageal inflammation.
Helicobacter pylori Eradication: Used in combination with antibiotics for eradication therapy.