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Levonorgestrel

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Structure

  • Levonorgestrel is a potent synthetic progestogen, the levorotatory isomer of norgestrel, enhancing its progestational activity.

  • Chemical Formula: C₂₀H₂₉NO₂

    Formula of Levonorgestrel
Structure of Levonorgestrel
Structure of Levonorgestrel

Mode of Action

  • Progestogen Activity: Binds to progesterone recep

    tors, inhibiting ovulation and altering endometrial receptivity.

  • Cervical Mucus Thickening: Enhances cervical mucus viscosity, preventing sperm from reaching the ovum.

  • Endometrial Alteration: Thins the endometrial lining, reducing the likelihood of implantation.

Uses of Levonorgestrel

  • Oral Contraceptives: Widely used in combined oral contraceptive pills and progestin-only pills.

  • Emergency Contraception: Administered as a single-dose pill to prevent pregnancy after unprotected intercourse.

  • Menstrual Regulation: Helps in managing heavy menstrual bleeding and irregular cycles.


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