Structure of Lisinopril
Lisinopril is a long-acting, non-proteinogenic amino acid derivative ACE inhibitor with a lysine moiety.
Chemical Formula: C₁₉H₃₂N₂O₅
Mode of Action
ACE Inhibition: Similar to other ACE inhibitors, lisinopril blocks the conversion of angiotensin I to angiotensin II.
Vasodilation: Results in decreased systemic vascular resistance and blood pressure.
Renal Protection: Reduces proteinuria and slows progression of kidney disease.
Uses
Hypertension: Effective in reducing blood pressure with once-daily dosing.
Heart Failure: Improves symptoms and reduces mortality when combined with other therapies.
Post-Myocardial Infarction: Enhances survival and prevents adverse cardiac remodeling.
Diabetic Nephropathy: Protects renal function in diabetic patients by reducing glomerular pressure.