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Lisinopril

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Structure of Lisinopril

  • Lisinopril is a long-acting, non-proteinogenic amino acid derivative ACE inhibitor with a lysine moiety.

  • Chemical Formula: C₁₉H₃₂N₂O₅

Structure of Lisinopril
Structure of Lisinopril

Mode of Action

  • ACE Inhibition: Similar to other ACE inhibitors, lisinopril blocks the conversion of angiotensin I to angiotensin II.

  • Vasodilation: Results in decreased systemic vascular resistance and blood pressure.

  • Renal Protection: Reduces proteinuria and slows progression of kidney disease.

Uses

  1. Hypertension: Effective in reducing blood pressure with once-daily dosing.

  2. Heart Failure: Improves symptoms and reduces mortality when combined with other therapies.

  3. Post-Myocardial Infarction: Enhances survival and prevents adverse cardiac remodeling.

  4. Diabetic Nephropathy: Protects renal function in diabetic patients by reducing glomerular pressure.



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