Lisinopril

Structure of Lisinopril

• Lisinopril is a long-acting, non-proteinogenic amino acid derivative ACE inhibitor with a lysine moiety.

• Chemical Formula: C₁₉H₃₂N₂O₅

Structure of Lisinopril

Mode of Action

• ACE Inhibition: Similar to other ACE inhibitors, lisinopril blocks the conversion of angiotensin I to angiotensin II.

• Vasodilation: Results in decreased systemic vascular resistance and blood pressure.

• Renal Protection: Reduces proteinuria and slows progression of kidney disease.

Uses

1. Hypertension: Effective in reducing blood pressure with once-daily dosing.

2. Heart Failure: Improves symptoms and reduces mortality when combined with other therapies.

3. Post-Myocardial Infarction: Enhances survival and prevents adverse cardiac remodeling.

4. Diabetic Nephropathy: Protects renal function in diabetic patients by reducing glomerular pressure.