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Loratadine

BP-S-5-MEDICINAL CHEMISTRY
1 min read

Structure (Loratadine)

  • Loratadine is a second-generation antihistamine with a tricyclic structure containing a piperidine ring and an ester linkage.

  • Chemical Formula: C₂₁H₂₀ClNO₂

Structure of Loratadine
Structure of Loratadine

Mode of Action

  • Selective peripheral H₁-receptor antagonist with minimal CNS penetration, thus reducing sedation.

  • It provides long-lasting antihistaminic effects.

Uses

  • Allergic Rhinitis: Treats symptoms like sneezing, itching, and runny nose.

  • Chronic Urticaria: Alleviates hives and skin itching.

  • Non-Allergic Rhinitis: Effective in treating vasomotor rhinitis.


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