Structure
Lorcainide hydrochloride is a class IB antiarrhythmic agent similar to lidocaine, featuring an amide linkage and an aromatic ring. It exists as the hydrochloride salt to enhance solubility.
Chemical Formula: C₁₁H₁₉N₃O₂ · HCl
Mode of Action
Class IB Antiarrhythmic: Blocks fast sodium channels, shortening action potential duration and refractory period.
Selective on Ventricular Myocytes: Primarily affects ventricular tissues, reducing ventricular excitability.
Effect on Heart Rate: Minimal impact on atrial tissues, useful for ventricular arrhythmias without significant atrial suppression.
Uses of Lorcainide hydrochloride
Ventricular Arrhythmias: Treats ventricular tachycardia and ventricular fibrillation.
Post-Myocardial Infarction: Prevents arrhythmias during the acute and chronic phases.
Arrhythmic Syndromes: Used in specific cases like Brugada syndrome to stabilize cardiac rhythms.
Research: Employed in studies investigating antiarrhythmic mechanisms and drug efficacy.