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Mafenide acetate: Chemical Structure, Mechanism of Action, Uses & Side effects

sachinkumar244
1 min read

Chemical formula:

  • C7H10N2O2S (mafenide), C2H4O2 (acetate)

Structure of Mafenide acetate
Structure of Mafenide acetate

Mechanism of action:

  • Mafenide acetate is a sulfonamide derivative that inhibits bacterial dihydropteroate synthase, blocking the synthesis of folate and leading to bacterial cell death.

Uses:

  • Mafenide acetate is primarily used topically as a cream or solution for the prevention and treatment of infections in burn wounds.

Side effects:

  • Common side effects include local pain, burning, and itching at the application site. Systemic absorption may cause metabolic acidosis, especially in patients with large burn areas.

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