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Major Extra and Intracellular Electrolytes

Introduction

  • Intracellular Electrolytes are ions that conduct electricity when dissolved in water.

  • They play essential roles in various physiological processes, such as maintaining fluid balance, nerve conduction, and muscle function.

  • Electrolytes are present both inside and outside cells, with specific concentrations maintained to ensure proper cell function.

  • They contribute to various bodily functions, including maintaining fluid balance, enabling nerve impulses, muscle contractions, and supporting essential metabolic processes.

Major Physiological ions

Extracellular electrolytes:

1) Sodium (Na+):

  • Primary Role: The main cation in extracellular fluid.

  • Functions:

    • Maintaining fluid balance

    • Regulating blood pressure

    • Supporting nerve and muscle function

  • Sources: Table salt, processed foods, canned soups, condiments, snacks

  • Deficiency (Hyponatremia):

    • Symptoms: Muscle cramps, fatigue, headache, nausea, seizures

    • Severe Cases: Coma and death.

2) Chloride (Cl-):

  • Primary Role: The main anion in extracellular fluid.

  • Functions:

    • Maintaining fluid balance

    • Supporting acid-base balance

    • Regulating osmotic pressure

  • Sources: Table salt, processed foods, some vegetables

  • Deficiency (Hypochloremia):

  • Symptoms: Muscle cramps, weakness

  • Severe Cases: Metabolic alkalosis, respiratory depression.

3) Bicarbonate (HCO3-):

  • Primary Role: Acts as a buffer in extracellular fluid.

  • Functions:

    • Maintaining acid-base balance

    • Facilitating carbon dioxide transport

  • Sources: Produced endogenously through metabolic processes

  • Deficiency (Metabolic Acidosis):

    • Symptoms: Fatigue, rapid breathing, confusion

    • Severe Cases: Shock and death.

4) Calcium (Ca2+):

  • Primary Role: An essential extracellular cation, though in lower concentrations than sodium and chloride.

  • Functions:

    • Blood clotting

    • Bone health

    • Nerve conduction

    • Muscle function

  • Sources: Dairy products, leafy greens, fortified foods, fish with edible bones

  • Deficiency (Hypocalcemia):

    • Symptoms: Muscle cramps, numbness, tingling, seizures

    • Severe Cases: Osteoporosis, rickets.

Intracellular electrolytes:

1) Potassium (K+):

  • Primary Role: The main cation in intracellular fluid.

  • Functions:

    • Maintaining cell membrane potential

    • Nerve conduction

    • Muscle function

  • Sources: Bananas, oranges, leafy greens, potatoes, tomatoes, yogurt

  • Deficiency (Hypokalemia):

    • Symptoms: Muscle weakness, cramps, fatigue, constipation

    • Severe Cases: Heart arrhythmias, paralysis.

2) Magnesium (Mg2+):

  • Primary Role: An essential intracellular cation.

  • Functions:

    • Protein synthesis

    • Muscle function

    • Energy metabolism

    • Enzyme regulation

  • Sources: Nuts, seeds, legumes, whole grains, leafy greens

  • Deficiency (Hypomagnesemia):

    • Symptoms: Muscle cramps, tremors, fatigue, loss of appetite

    • Severe Cases: Seizures, heart arrhythmiass.

3) Phosphate (PO43-):

  • Primary Role: The primary anion in intracellular fluid.

  • Functions:

    • Energy metabolism (as part of ATP)

    • Cell signaling

    • Nucleic acid and bone formation

  • Sources: Dairy products, meat, fish, whole grains, nuts

  • Deficiency (Hypophosphatemia):

    • Symptoms: Muscle weakness, bone pain

    • Severe Cases: Rickets, osteomalacia.

4) Sulphate (SO42-):

  • Primary Role: An important intracellular anion.

  • Functions:

    • Protein synthesis

    • Detoxification

    • Structural molecule formation

  • Sources: Animal proteins, legumes, some vegetables

  • Deficiency: Rare and not well-established, but severe deficiency may affect protein synthesis and detoxification processes


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