Inflammation is regulated by various chemical mediators that orchestrate the inflammatory response.
These mediators can be derived from cells or plasma and have different roles in initiating and sustaining inflammation.
Mediators of inflammation are substances that play key roles in initiating and regulating inflammatory responses.
Here are the main types:
Histamine: Released by mast cells and basophils, it increases vascular permeability and causes vasodilation.
Prostaglandins: Lipid compounds that intensify inflammation by promoting vasodilation, fever, and pain.
Cytokines: Proteins such as interleukins and tumor necrosis factor (TNF) that modulate the immune response and inflammation.
Chemokines: A subset of cytokines that attract white blood cells to sites of infection or injury.
Complement System: A series of proteins that enhance the ability of antibodies and phagocytic cells to clear microbes and damaged cells.
Leukotrienes: Lipid compounds that mediate allergic and inflammatory responses, increasing vascular permeability and attracting leukocytes.
These mediators work together to protect the body but can also contribute to chronic
inflammation and disease if not properly regulated.