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Melphalan

Structure of Melphalan

Melphalan is an alkylating agent belonging to the nitrogen mustard family, featuring a phenylalanine moiety.

Chemical Formula: C₁₁H₁₄Cl₂N₂O₂

Mode of Action

  • DNA Alkylation: Forms crosslinks with DNA, disrupting DNA synthesis and function.

  • Inhibits Cell Division: Prevents cancer cell proliferation by damaging genetic material.

  • Induces Apoptosis: Triggers programmed cell death in malignant cells.

Uses

  • Multiple Myeloma: In combination with other chemotherapeutic agents.

  • Ovarian Cancer: As part of chemotherapy regimens.

  • Breast Cancer: Treatment of metastatic disease.

  • Hodgkin's Lymphoma: In certain treatment protocols.


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