Structure of Melphalan
Melphalan is an alkylating agent belonging to the nitrogen mustard family, featuring a phenylalanine moiety.
Chemical Formula: C₁₁H₁₄Cl₂N₂O₂
Mode of Action
DNA Alkylation: Forms crosslinks with DNA, disrupting DNA synthesis and function.
Inhibits Cell Division: Prevents cancer cell proliferation by damaging genetic material.
Induces Apoptosis: Triggers programmed cell death in malignant cells.
Uses
Multiple Myeloma: In combination with other chemotherapeutic agents.
Ovarian Cancer: As part of chemotherapy regimens.
Breast Cancer: Treatment of metastatic disease.
Hodgkin's Lymphoma: In certain treatment protocols.