Chemical Structure:
C15H21NO2 · HCl
Mechanism of Action:
Acts as a mu-opioid receptor agonist. It also has effects on the serotonin system, which can lead to serotonin syndrome when combined with other serotonergic drugs.
Uses:
Pain Management: Particularly for acute pain and used in anesthesia.
Shivering: Can be used to treat postoperative shivering.
Side Effects:
Serotonin Syndrome: When combined with serotonergic agents.
Typical Opioid Side Effects: Such as respiratory depression, sedation, nausea, and constipation.
CNS Excitation: May cause tremors, muscle twitches, and seizures, especially in higher doses or in renal impairment due to accumulation of its metabolite normeperidine.