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Mepivacaine

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Structure

  • Mepivacaine is an amide-type local anesthetic similar to lidocaine but with a methyl group attached to the diethylaminoethyl side chain, enhancing its potency.

  • Chemical Formula: C₁₄H₂₈N₂O

    Formula of Mepivacaine
Structure of Mepivacaine
Structure of Mepivacaine

Mode of Action

  • Sodium Channel Blockade: Blocks voltage-gated sodium channels, preventing nerve impulse transmission.

  • Membrane Stabilization: Reduces neuronal excitability by stabilizing nerve membranes.

Uses

  • Local Anesthesia: Used in dental procedures, minor surgical interventions, and obstetric anesthesia.

  • Topical Preparations: Applied to mucous membranes and skin for temporary numbing.

  • Infiltration Anesthesia: Injected to provide localized numbness during medical procedures.

Side Effects

  • Local Reactions: Pain, redness, or swelling at the injection site.

  • Systemic Toxicity: Potential CNS excitation (e.g., seizures) and cardiovascular effects (e.g., arrhythmias) with excessive doses.


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