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Methysergide: Chemical Structure, Mechanism of Action, Uses & Side Effects

Chemical Structure/Formula:

  • C21H27N3O2

Structure of Methysergide
Structure of Methysergide

Mechanism of Action:

  • Methysergide is a serotonin antagonist and an ergot derivative. It inhibits the action of serotonin on vascular and uterine smooth muscle.

Uses:

  • It is used for the prevention of migraine headaches and cluster headaches.

Side Effects:

  • Side effects include nausea, vomiting, abdominal pain, and dizziness. Long-term use can lead to serious complications like fibrosis, affecting the heart, lungs, and retroperitoneal area.

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