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Mifepristone

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Structure

  • Mifepristone is a synthetic steroid with both anti-glucocorticoid and anti-progestational properties, featuring a RU486 core structure.

  • Chemical Formula: C₂₈H₃₈N₂O₄

Structure of Mifepristone
Structure of Mifepristone

Mode of Action

  • Progesterone Receptor Antagonism: Blocks progesterone receptors, disrupting the uterine lining and preventing implantation.

  • Glucocorticoid Receptor Antagonism: Inhibits cortisol receptors, used in managing hypercortisolism.

  • Induction of Labor: Can induce labor by causing uterine contractions.

Uses of Mifepristone

  • Medical Abortion: Combined with misoprostol to terminate early pregnancies by preventing implantation and inducing uterine contractions.

  • Cushing’s Syndrome: Used to manage endogenous hypercortisolism by blocking cortisol receptors.

  • Emergency Contraception: Sometimes used off-label to prevent pregnancy after unprotected intercourse.


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