Mifepristone

Structure

• Mifepristone is a synthetic steroid with both anti-glucocorticoid and anti-progestational properties, featuring a RU486 core structure.

• Chemical Formula: C₂₈H₃₈N₂O₄

Structure of Mifepristone

Mode of Action

• Progesterone Receptor Antagonism: Blocks progesterone receptors, disrupting the uterine lining and preventing implantation.

• Glucocorticoid Receptor Antagonism: Inhibits cortisol receptors, used in managing hypercortisolism.

• Induction of Labor: Can induce labor by causing uterine contractions.

Uses of Mifepristone

• Medical Abortion: Combined with misoprostol to terminate early pregnancies by preventing implantation and inducing uterine contractions.

• Cushing’s Syndrome: Used to manage endogenous hypercortisolism by blocking cortisol receptors.

• Emergency Contraception: Sometimes used off-label to prevent pregnancy after unprotected intercourse.