Chemical formula:
C12H13ClN4
Mechanism of action:
Pyrimethamine is a selective inhibitor of Plasmodium DHFR, blocking the synthesis of nucleic acids in the parasite.
Uses:
Pyrimethamine is used in combination with sulfadoxine (Fansidar®) to treat uncomplicated P. falciparum malaria in areas with chloroquine resistance.
It is also used in combination with other drugs for the treatment and prevention of toxoplasmosis.
Side effects:
Nausea, Vomiting, Diarrhea, abdominal pain, headache, dizziness and rash.
Rare but serious side effects include bone marrow suppression, hepatotoxicity, and severe skin reactions.