Structure of Mitotane
Mitotane is an adrenolytic agent structurally related to the insecticide DDT, featuring a dichlorodiphenyltrichloroethane (DDT) core with modifications.
Chemical Formula: C₁₈H₁₂Cl₄O
Structure of Mitotane
Mode of Action
Adrenolytic Effects: Specifically targets and destroys adrenal cortical cells.
Steroidogenesis Inhibition: Reduces cortisol production by inhibiting enzymes involved in steroid synthesis.
Apoptosis Induction: Promotes programmed cell death in adrenal cortical carcinoma cells.
Uses
Adrenal Cortical Carcinoma: As an adjuvant therapy post-surgery.
Cushing's Syndrome: Particularly ectopic or adrenal in origin.
Management of Adrenal Insufficiency: By reducing excess hormone production.
Breast Cancer: In certain cases where hormone modulation is beneficial.