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Monobactams (Aztreonam)

BP-S-6-Medicinal Chemistry III
1 min read

Chemical Structure / Formula of Monobactams (Aztreonam)

  • Formula: C13H17N5O8S2 Monobactams (Aztreonam)

  • Unique feature: Single β-lactam ring (monocyclic), unlike penicillins and cephalosporins.

Chemical Structure of Monobactams (Aztreonam)
Chemical Structure of Monobactams (Aztreonam)

Mechanism of Action

  • Binds to PBP-3, inhibiting bacterial cell wall synthesis.

  • Selective for aerobic Gram-negative bacteria, including Pseudomonas aeruginosa.

Uses

  • Treats serious Gram-negative infections, including pneumonia, sepsis, and UTIs.

  • Safe for penicillin-allergic patients (no cross-reactivity).

Side Effects

  • Common: Rash, nausea.

  • Serious: Liver enzyme elevation, eosinophilia.


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