Nalidixic Acid: Chemical Structure, Mechanism of Action, Uses & Side effects

Chemical formula:

• C12H12N2O3

Structure of Nalidixic

Mechanism of action:

• Nalidixic acid inhibits bacterial DNA replication by targeting DNA gyrase (topoisomerase II) and topoisomerase IV, preventing the unwinding of DNA and subsequent replication.

Uses:

• Nalidixic acid is primarily used to treat uncomplicated lower urinary tract infections caused by susceptible Gram-negative bacteria.

Side effects:

• Side effects can include gastrointestinal disturbances, hypersensitivity reactions, central nervous system (CNS) effects (e.g., headache, dizziness), and phototoxicity.