Structure
Nesiritide Chemical Structure – C143H244N50O42S4
Mode of action
In endothelial cells and vascular smooth muscle, it interacts to the particulate guanylate cyclase receptor. Which increase cGMP concentration, which cause vasodilation, resulting decrease in blood pressure.
It also inhibits the RAAS system.
Uses
It For the treatment of individuals with severe chronic congestive heart failure, this drug is administered intravenously.
Also helps in the vasodilation and diuresis.