Structure
Nesiritide is a recombinant form of B-type natriuretic peptide (BNP), comprising a 32-amino acid polypeptide with disulfide bonds stabilizing its structure.
Chemical Formula: C₁₈H₂₇N₅O₅S₆
Mode of Action
Guanylate Cyclase Activation: Binds to natriuretic peptide receptors, increasing cyclic GMP levels.
Vasodilation: Causes relaxation of vascular smooth muscle, reducing systemic vascular resistance and afterload.
Natriuresis and Diuresis: Promotes excretion of sodium and water by the kidneys.
Renal Perfusion Enhancement: Improves renal blood flow and glomerular filtration rate (GFR).
Uses of Nesiritide
Acute Decompensated Heart Failure: Provides rapid relief of symptoms by reducing preload and afterload.
Renal Dysfunction: Enhances renal perfusion and function in congestive heart failure.
Hypertensive Crises: Utilized in managing severe hypertension by promoting vasodilation.
Pulmonary Edema: Reduces fluid accumulation in the lungs by promoting diuresis.